Binding of oxygen with haemoglobin is primarily related to `:`

Options

A. Partial pressure of `O_(2)`
B. Partial pressure of `CO_(2)`
C. `H^(+)` ion concentration
D. Temperature

Answer

To answer the question regarding the binding of oxygen with hemoglobin, we can follow these steps:

### Step-by-Step Solution:

1. **Understanding Hemoglobin and Oxygen Binding**: Hemoglobin is a protein in red blood cells that binds to oxygen. The binding of oxygen to hemoglobin forms oxyhemoglobin (HbO2), which is essential for transporting oxygen from the lungs to the tissues.

2. **Identifying the Factors Influencing Binding**: The binding of oxygen to hemoglobin is influenced by several factors, including:
- Partial pressure of oxygen (pO2)
- Partial pressure of carbon dioxide (pCO2)
- H+ ion concentration (pH)
- Temperature

3. **Determining the Primary Factor**: Among the factors listed, the primary factor that directly affects the binding of oxygen to hemoglobin is the partial pressure of oxygen. An increase in the partial pressure of oxygen leads to an increased binding capacity of hemoglobin for oxygen.

4. **Understanding Secondary Factors**: While partial pressure of oxygen is the primary factor, the other factors such as partial pressure of CO2, H+ ion concentration, and temperature also play a role but are considered secondary. They can influence the affinity of hemoglobin for oxygen but are not the primary determinants.

5. **Conclusion**: Therefore, the binding of oxygen with hemoglobin is primarily related to the partial pressure of oxygen.

### Final Answer:
The binding of oxygen with hemoglobin is primarily related to the **partial pressure of oxygen**.

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