In Drosophila single mating could produce large number of progeny flies.

Answer

### Step-by-Step Solution:

1. **Understanding Drosophila Reproduction**:
- Drosophila, commonly known as fruit flies, reproduce sexually. This means that both male and female flies are involved in the mating process.

2. **Mating Process**:
- During a single mating event, the male Drosophila transfers sperm to the female. This fertilization process is crucial for the production of offspring.

3. **Egg Production**:
- After mating, the female Drosophila can lay a significant number of eggs. It is known that a single female can produce between 100 to 400 eggs after one mating event.

4. **Fertilization of Eggs**:
- The eggs produced by the female are fertilized due to the sperm received from the male during mating. This ensures that the eggs will develop into embryos.

5. **Development of Offspring**:
- Once the eggs are fertilized, they hatch into larvae. The larvae then undergo development to become adult flies.

6. **Conclusion**:
- Given the ability of a single female Drosophila to produce a large number of eggs (100 to 400) after one mating, it is accurate to say that a single mating can indeed produce a large number of progeny flies.

### Final Answer:
The statement is **True**. In Drosophila, a single mating can produce a large number of progeny flies.

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