What is the reason of arrested oogenesis in female upto puberty ?

Options

A. Nutrition is not properly available
B. Follicles are not matured
C. Some inhibitory factors released by granulosa cells or follicular cells
D. Inactivation of germinal epithelium of ovary

Answer

### Step-by-Step Solution:

1. **Understanding Oogenesis**: Oogenesis is the process of egg (ovum) formation in females, which begins during the embryonic stage. It is different from spermatogenesis, which occurs after puberty.

2. **Formation of Oogonia**: During the embryonic stage, a fixed number of oogonia (the precursor cells for oocytes) are formed. After birth, no new oogonia are produced.

3. **Arrested Development**: The oogonia undergo meiosis I during the embryonic stage but do not complete it. Instead, they are arrested in the diplotene stage of prophase I. At this point, they are referred to as primary oocytes.

4. **Granulosa Cells**: As the primary oocytes develop, they become surrounded by granulosa cells, which form a protective layer around them. These granulosa cells play a crucial role in the maturation of the oocyte.

5. **Inhibitory Factors**: The granulosa cells release certain inhibitory factors that prevent the completion of meiosis I. This is a key reason why oogenesis is arrested until puberty.

6. **Follicle Maturation**: The follicles containing the primary oocytes do not mature fully until the onset of puberty. At puberty, hormonal changes trigger the maturation of these follicles, leading to the resumption of oogenesis.

7. **Conclusion**: The primary reasons for the arrested oogenesis in females up to puberty include the presence of inhibitory factors released by granulosa cells and the immature state of the follicles.

### Final Answer:
The reason for arrested oogenesis in females up to puberty is primarily due to the inhibitory factors released by granulosa cells that prevent the completion of meiosis I.

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