Zona pellucida is synthesized by:-

Options

A. Follicle
B. Oocyte
C. Both follicle cell and oocyte
D. Granulosa cells

Answer

### Step-by-Step Solution:

1. **Understanding Zona Pellucida**:
- The zona pellucida is a glycoprotein layer that surrounds the mammalian oocyte (egg cell). It plays a crucial role in fertilization by protecting the oocyte and facilitating sperm binding.

2. **Identifying the Source of Synthesis**:
- The synthesis of the zona pellucida is attributed to two main sources: the oocyte itself and the surrounding follicle cells (also known as granulosa cells).

3. **Analyzing the Options**:
- The question provides several options regarding which cells synthesize the zona pellucida:
- A) Follicle cells
- B) Oocyte
- C) Both follicle cells and the oocyte
- D) Granulosa cells

4. **Evaluating the Options**:
- **Option A**: Follicle cells - This is partially correct as follicle cells contribute to the zona pellucida.
- **Option B**: Oocyte - This is also correct since the oocyte secretes the zona pellucida.
- **Option C**: Both follicle cells and the oocyte - This is the most comprehensive and correct answer as it includes both sources.
- **Option D**: Granulosa cells - This is synonymous with follicle cells and is also correct, but does not encompass the oocyte.

5. **Conclusion**:
- The most appropriate answer is **Option C: Both follicle cells and the oocyte**, as both contribute to the synthesis of the zona pellucida.