Which of the following does not pass through hepatopancreatic duct?

Options

A. Enzymes
B. Alkaline bile
C. Insulin
D. Bilirubin

Answer

To solve the question "Which of the following does not pass through the hepatopancreatic duct?", we will analyze each of the given options: enzymes, alkaline bile, insulin, and bilirubin.

### Step-by-Step Solution:

1. **Understanding the Hepatopancreatic Duct**:
- The hepatopancreatic duct, also known as the ampulla of Vater, is a common duct that allows the passage of bile and pancreatic juices into the small intestine. It connects the liver and pancreas to the duodenum.

2. **Analyzing Each Option**:
- **Enzymes**:
- Pancreatic enzymes (like amylase, lipase, and proteases) are secreted by the pancreas and do pass through the hepatopancreatic duct into the small intestine. Therefore, this option does pass through the duct.

- **Alkaline Bile**:
- Bile, which is produced by the liver, contains alkaline substances that help in digestion. Bile passes through the hepatopancreatic duct into the small intestine. Thus, this option also passes through the duct.

- **Insulin**:
- Insulin is a hormone produced by the islets of Langerhans in the pancreas. It is an endocrine secretion, meaning it is released directly into the bloodstream and does not pass through any duct. Therefore, this option does not pass through the hepatopancreatic duct.

- **Bilirubin**:
- Bilirubin is a waste product formed from the breakdown of red blood cells and is excreted in bile. Since bile passes through the hepatopancreatic duct, bilirubin also passes through the duct.

3. **Conclusion**:
- Among the options provided, insulin is the only substance that does not pass through the hepatopancreatic duct. The correct answer is **insulin**.

### Final Answer:
**Insulin does not pass through the hepatopancreatic duct.**