Identify the wrong statement.

Options

A. Hyposecretion of corticosteroids causes cushing's disease
B. Hypersecretion of thyroxine in adults causes Grave's disease
C. Hyposecretion of adrenal medullary hormones causes addison's disease
D. Simple goilter is an endemic disease

Answer

To identify the wrong statement from the provided options, we will analyze each statement one by one.

### Step-by-Step Solution:

1. **Analyze Statement 1**:
- Statement: "Hyposecretion of corticosteroids causes Cushing's disease."
- Explanation: Cushing's disease (or Cushing's syndrome) is characterized by high levels of cortisol in the body, which is a result of hypersecretion (excess production) of corticosteroids from the adrenal glands. Therefore, this statement is incorrect because it states hyposecretion (low levels) leads to Cushing's disease, which is not true.

2. **Analyze Statement 2**:
- Statement: "Hyposecretion of thyroxine in adults causes Graves disease."
- Explanation: Graves disease is actually associated with hypersecretion of thyroid hormones, leading to hyperthyroidism. Thus, this statement is also incorrect. However, it is important to note that the statement is about hyposecretion, which does not cause Graves disease.

3. **Analyze Statement 3**:
- Statement: "Hyposecretion of adrenal medullary hormones causes Addison's disease."
- Explanation: Addison's disease is caused by the hyposecretion of hormones from the adrenal cortex, particularly cortisol and sometimes aldosterone. Therefore, this statement is correct as it correctly associates Addison's disease with hyposecretion.

4. **Analyze Statement 4**:
- Statement: "Simple goiter is an endemic disease."
- Explanation: Simple goiter is indeed associated with iodine deficiency and can be endemic in areas where iodine is lacking in the diet. Therefore, this statement is correct.

### Conclusion:
The wrong statement is **Statement 1**: "Hyposecretion of corticosteroids causes Cushing's disease."