Mutation is due to

Options

A. 1)Loss of a segment of DNA
B. 2)Gain of a segment of DNA
C. 3)Change in a single base pair of DNA
D. 4)All of these

Answer

### Step-by-Step Solution:

1. **Understanding Mutation**:
- Mutation refers to any alteration or change in the nucleotide sequence of DNA. This can occur in the genome of an organism, affecting how genes are expressed and how traits are inherited.

2. **Analyzing the Options**:
- **Option 1**: Loss of a segment of DNA - This is known as deletion, which is a type of mutation.
- **Option 2**: Gain of a segment of DNA - This is referred to as insertion, which is also a type of mutation.
- **Option 3**: Change in a single base pair of DNA - This is known as point mutation, another type of mutation.

3. **Conclusion**:
- Since all three options (deletion, insertion, and point mutation) are recognized types of mutations, the correct answer must encompass all of these possibilities.

4. **Final Answer**:
- Therefore, the correct option is **Option 4: All of these**.