Gametocytes of Plasmodium

Options

A. Enter from man to mosquito
B. mosquito to man
C. Both 1 and 2
D. only found in man

Answer

### Step-by-Step Solution:

1. **Understanding Gametocytes of Plasmodium**:
- Gametocytes are specialized sexual precursor cells of the Plasmodium parasite, which causes malaria. They are crucial for the transmission of malaria.

2. **Transmission Process**:
- The transmission of Plasmodium occurs between two hosts: humans and mosquitoes. Specifically, the Anopheles mosquito is the vector responsible for transmitting the malaria parasite.

3. **Maturation of Gametocytes**:
- In humans, gametocytes of Plasmodium accumulate and mature in the bone marrow. This is where they develop before being transmitted to mosquitoes.

4. **Infection Cycle**:
- When an infected female Anopheles mosquito bites a human, it ingests the gametocytes present in the human's blood. This is the first part of the transmission cycle, where the gametocytes move from man to mosquito.

5. **Further Transmission**:
- After the mosquito ingests the gametocytes, they undergo further development within the mosquito. When the mosquito bites another human, it injects the Plasmodium parasites into the new host, completing the cycle of transmission (from mosquito to man).

6. **Conclusion**:
- Therefore, the gametocytes of Plasmodium are involved in both transmission pathways: from man to mosquito and from mosquito to man. Thus, the correct answer to the question is that gametocytes of Plasmodium enter from both man to mosquito and mosquito to man.

### Final Answer:
The correct options are: **Both one and two**.

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