Which colligative property is preferred for the molar mass determination of macromolecules (i.e.,proteins and polmers)?

Explanation

a. The molecular weight of macromolecules (e.g., proteins and polymers ) is very high, hence the measured values (e.g.,`(DeltaP)/(P^(@)),DeltaT_(f) ,DeltaT_(b)`) will be very less and thus cannot be determined accurately. Although the osmotic pressure will also be less but it can be measured, since it is not the difference is pressure as in the cases of other colligative properties.
b. The osmotic pressure is measured at room temperature. So the properties of macromolecules do not change, whereas all other methods require heating which changes the properties of macromolecules, e.g., the proteins may coagulate and polymers may decompose at higher temperature.