Splitting of the centromere is a significance feature of

Options

A. Anaphase
B. Anaphase I
C. Anaphase II
D. Both (a) and (c)

Answer

To solve the question regarding the significance of the splitting of the centromere, we will analyze the options provided and determine which phase of cell division is characterized by this feature.

### Step-by-Step Solution:

1. **Understanding Centromere Splitting**:
The centromere is the region of a chromosome where the two sister chromatids are joined together. The splitting of the centromere allows the sister chromatids to separate and move toward opposite poles of the cell during cell division.

2. **Analyzing the Options**:
- **Option A: Anaphase**:
In anaphase, the centromeres of the chromosomes split, allowing the sister chromatids to separate and move toward opposite poles. This is a key characteristic of anaphase in both mitosis and meiosis.
- **Option B: Anaphase I**:
In anaphase I of meiosis, homologous chromosomes are separated, but the centromeres do not split. Therefore, the sister chromatids remain attached at their centromeres.
- **Option C: Anaphase II**:
In anaphase II of meiosis, the centromeres split, and the sister chromatids are separated and move towards opposite poles, similar to anaphase in mitosis.

3. **Conclusion**:
The splitting of the centromere is a significant feature of both **Anaphase** and **Anaphase II**. However, since the question asks for a single answer, the most direct answer is **Anaphase**.

### Final Answer:
The splitting of the centromere is a significant feature of **Anaphase**.