Protein found in a biological system with a unique three-dimensional structure and biological activity is called a native protein. When a protein in its native form, is subjected to a physical change like change in temperature or a chemical change like, change in pH, denaturation of protein takes place. Explain the cause.

Explanation

**Step-by-Step Solution:**

1. **Understanding Native Proteins**: Native proteins are proteins that are folded into their unique three-dimensional structures, which are essential for their biological functions. This structure is stabilized by various types of bonds, including hydrogen bonds, ionic bonds, disulfide bridges, and hydrophobic interactions.

2. **Role of Peptide Linkages**: Proteins are made up of amino acids linked together by peptide bonds. The sequence of amino acids determines the protein's structure and function. The peptide bond forms between the carboxyl group of one amino acid and the amino group of another, releasing a molecule of water.

3. **Stability of Protein Structure**: The three-dimensional structure of a protein is maintained by non-covalent interactions, particularly hydrogen bonds. These bonds form between the hydrogen atom of an NH group and the oxygen atom of a carbonyl group in the protein's backbone, contributing to the protein's stability.

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