Which of the following carbon is anomeric in glucose

Options

A. C-1 carbon
B. C-2 carbon
C. C-5 carbon
D. C-6 carbon

Explanation

To determine which carbon is the anomeric carbon in glucose, we can follow these steps:

### Step 1: Understand the Structure of Glucose
Glucose is a six-carbon sugar (hexose) that can exist in both linear and cyclic forms. The cyclic form is more common in solution.

### Step 2: Identify the Cyclic Form
In the cyclic form of glucose, the first carbon (C1) is the carbon that is involved in the formation of the cyclic structure. This carbon is also known as the anomeric carbon.

### Step 3: Define Anomeric Carbon
The anomeric carbon is defined as the carbon that was the carbonyl carbon (C=O) in the open-chain form of the sugar. When the sugar cyclizes, this carbon becomes a chiral center and can exist in two different configurations (alpha and beta).

### Step 4: Analyze the Configuration
In the case of glucose:
- In alpha-D-glucose, the hydroxyl group (-OH) on the anomeric carbon (C1) is positioned on the opposite side of the CH2OH group (C6).
- In beta-D-glucose, the hydroxyl group (-OH) on the anomeric carbon (C1) is positioned on the same side as the CH2OH group (C6).

### Step 5: Conclusion
Thus, the anomeric carbon in glucose is the first carbon (C1).

### Final Answer
The anomeric carbon in glucose is **carbon 1 (C1)**.

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