Aspirin inhibits the synthesis of _______ which stimulate inflammation in the tissue and cause pain

Answer

To solve the question, we need to identify the substance that aspirin inhibits the synthesis of, which is responsible for stimulating inflammation in tissues and causing pain.

### Step-by-Step Solution:

1. **Understanding Aspirin's Function**: Aspirin is a medication commonly used to relieve pain, reduce inflammation, and lower fever. It is known for its anti-inflammatory properties.

2. **Identifying the Target of Aspirin**: Aspirin works by inhibiting certain enzymes in the body. Specifically, it inhibits the synthesis of prostaglandins, which are lipid compounds that have several important functions, including the promotion of inflammation and pain.

3. **Connecting Prostaglandins to Inflammation and Pain**: Prostaglandins are produced in response to injury or illness and are responsible for the symptoms of inflammation, such as swelling, redness, and pain. By inhibiting their synthesis, aspirin effectively reduces these symptoms.

4. **Final Answer**: Therefore, the substance that aspirin inhibits the synthesis of, which stimulates inflammation in the tissue and causes pain, is **prostaglandins**.

### Final Answer:
Aspirin inhibits the synthesis of **prostaglandins**.